Premium
INTERFERON INDUCTION IN HUMAN CELL CULTURES BY SMALL MOLECULAR INDUCERS (TILORONE AND ACRIDINES)
Author(s) -
DEGRæ MIKLOS,
GLÁZ ERVIN T.
Publication year - 1977
Publication title -
acta pathologica microbiologica scandinavica section b microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-131X
DOI - 10.1111/j.1699-0463.1977.tb01695.x
Subject(s) - sendai virus , interferon , lymphoblast , biology , cell culture , inducer , human cell , blastoid , virology , virus , immunology , biochemistry , genetics , gene , lymphoma , mantle cell lymphoma
Attempts were made to stimulate interferon production in human cell cultures by two related acridin drugs, mepacrine and Acranil. Tilorone was included for comparison. In human embryo lung fibroblasts and in normal human leukocytes only tilorone stimulated some inter‐feron production. All three drugs stimulated modest interferon production in two lympho‐ blastoid cell lines. All three drugs enhanced the Sendai virus‐induced interferon production in lymphoblastoid cells.