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PSEUDOSARCOMATOUS PROLIFERATIVE LESIONS OF SOFT TISSUE WITH OR WITHOUT BONE FORMATION
Author(s) -
Dahl Ingvar,
Angervall Lennart
Publication year - 1977
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1977.tb00449.x
Subject(s) - medicine , nodular fasciitis , pathology , soft tissue , myositis , lesion , fasciitis , histology , subcutaneous tissue , cartilage , anatomy , surgery
The clinical observations, the structural appearance and the light microscopy of 18 cases of pseudosarcomatous proliferative lesions of soft tissue are described. The study indicates that a close relationship exists between nodular fasciitis, proliferative fasciitis and proliferative myositis. The descriptive term “pseudosarcomatous proliferative lesion of soft tissue” is proposed for these lesions and mixed forms with or without bone formation. Seven patients were females and 11 were males; the ages ranged between 37 years and 81 years, with a median of 58.5 years. Seven lesions were situated entirely or almost entirely within the subcutaneous tissue, and 11 lesions within striated muscle, with a predilection for muscles of the trunk and proximal regions of the extremities. The predominant proliferating cells were large cells, resembling ganglion cells. The histochemical study of the myxoid matrix indicated the presence of chondroitin 4‐ and/or 6‐ sulfates. The gross and the light microscopic appearances of the lesions were compatible with the diagnosis of proliferative fasciitis in 6 cases, and proliferative myositis in 9 cases. Four lesions showed mixed forms between proliferative myositis and proliferative fasciitis. Nodular fasciitis‐like areas were evident in 14 cases. Four lesions showed bone and cartilage formation. Follow‐up information was available in all patients. The follow‐up period ranged from 9 months to 17 years, with a median of 11 years. Four patients died from intercurrent diseases; the remaining 14 patients are alive and well, indicating the perfectly benign clinical course. Awareness of the existence of pseudosarcomatous proliferative lesions of soft tissue and a knowledge of their characteristic gross structural and variable light microscopic appearances is mandatory for the avoidance of misinterpreting these lesions as sarcoma.