Premium
OCCURRENCE OF AMYLOIDOSIS SECONDARY TO THE INDUCTION OF EXPERIMENTAL HYPERTENSION IN MICE
Author(s) -
Svendsen Ulrik Gerner
Publication year - 1977
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1977.tb00425.x
Subject(s) - amyloidosis , medicine , lesion , kidney , pathology , nephrectomy , aplasia , amyloid fibril , infarction , disease , myocardial infarction , amyloid β
Following the induction of three different forms of experimental hypertension, deposits of amyloid were found in the spleens of 5–20 per cent of the mice late in the course of the hypertension. Amyloidosis was found in nude (with genetical aplasia of the thymus) as well as in haired (normal) mice. The highest frequency of amyloidosis was observed in mice with hypertension due to partial infarction of one kidney and contralateral nephrectomy. The hypertensive vascular disease, involving lesion of the vessels and of the organs supplied by the affected vessels, is believed to represent a stimulus for the reticulo endothelial system (RES) with development of amyloidosis as a secondary event.