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THE EFFECT OF PHENYLBUTAZONE AND CHLORAMPHENICOL ON PHAGOCYTOSIS OF RADIOLABELLED CANDIDA ALBICANS BY HUMAN MONOCYTES CULTURED IN VITRO
Author(s) -
ØDEGAARD ARNE,
LAMVIK JON
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1976.tb03597.x
Subject(s) - phagocytosis , phenylbutazone , chloramphenicol , candida albicans , in vitro , microbiology and biotechnology , yeast , chemistry , biology , antibiotics , biochemistry , pharmacology
The effect of phenylbutazone and chloramphenicol on the function of blood monocytes cultured in vitro was studied. Both drugs had an inhibitory effect on the engulfment stage of phagocytosis. While a moderate effect only of chloramphenicol on digestion of engulfed yeast particles was found, phenylbutazone caused a marked reduction of the digestion of engulfed particles. Concomitant with this reduction of digestive ability, the lysosomes showed no morphological alterations as observed in control cultures without drug addition, indicating a lack of fusion between the engulfed particles and lysosomes in the presence of phenylbutazone.