Premium
THE EFFECT OF STEROIDS ON ADHESIVENESS, ROSETTE‐FORMING ABILITY AND SURVIVAL OF CULTURED, HUMAN MONONUCLEAR CELLS
Author(s) -
VIKEN K. E.
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1976.tb03593.x
Subject(s) - peripheral blood mononuclear cell , corticosterone , in vitro , testosterone (patch) , lysis , endocrinology , medicine , biology , andrology , immunology , hormone , biochemistry
The effect of different steroids on human mononuclear blood cells during the first 90 minutes of culture in vitro was tested. Cortisol and testosterone were found to increase the ability of lymphocytes to adhere on plastic surfaces. None of the other steroids tested exhibited this effect. Cortisol and corticosterone were found to reduce the number of surviving macrophages in the culture dishes, tested 4 to 8 days after the exposure to the drugs. No lysis of mononuclear cells could be detected following addition of cortisol in doses up to 10‐ 1 mg/ml. The findings support the previous statements that human lymphocytes are more cortisol‐resistant than those of mouse, rat and rabbit.