Premium
ACQUIRED RESISTANCE OF BCG‐VACCINATED RED MICE TO INFECTION WITH LISTERIA MONOCYTOGENES
Author(s) -
Jespersen Andr.
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section b microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-131X
DOI - 10.1111/j.1699-0463.1976.tb01936.x
Subject(s) - listeria monocytogenes , vaccination , virulence , listeria , potency , bcg vaccine , intraperitoneal injection , microbiology and biotechnology , medicine , colony forming unit , virology , immunology , biology , bacteria , pharmacology , in vitro , biochemistry , genetics , gene
Infection experiments have shown that red mice, belonging to the vole family, could be infected with Listeria monocytogenes and that they were almost as susceptible to intravenous infection as CF 1 mice. Vaccination of red mice with BCG induced a resistance which could be demonstrated by prolongation of the survival time of the animals after challenge with Listeria. The resistance was greatest in the second and third week after vaccination and was considerably higher after intravenous injection of BCG vaccine than after intraperitoneal or subcutaneous injection. On the basis of studies concerning the dose of vaccine, the route of vaccination, and the interval between vaccination and challenge, a method by which to evaluate the potency of a strain of BCG has been elaborated. By this method it was found that there was a significant difference between the resistance produced by a strain of BCG which is weakly virulent and one which is strongly virulent for hamsters.