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EXPERIMENTAL PORCINE NEPHROPATHY: CHANGES OF RENAL FUNCTION AND STRUCTURE PERORALLY INDUCED BY CRYSTALLINE OCHRATOXIN A
Author(s) -
Krogh P.,
Elling F.,
GyrdHansen N.,
Hald B.,
Larsen A. E.,
Liliehøj E. B.,
Madsen A.,
Mortensen H. P.,
Ravnskov U.
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1976.tb00137.x
Subject(s) - ochratoxin a , nephropathy , chemistry , kidney , renal function , medicine , ochratoxin , urine , endocrinology , excretion , atrophy , urinary system , food science , biology , biochemistry , mycotoxin , diabetes mellitus
Nine pigs were fed crystalline ochratoxin A in amounts corresponding to a feed level of 1 mg per kg for 3 months. The only observable lesion developed was a kidney damage, identical to the naturally occurring porcine nephropathy. The changes of renal function was characterized by impairment of proximal tubular function, indicated by a decrease of the ratio Tm PAH /C In , of the ability to concentrate urine, and by an increased urinary excretion of glucose. The decrease of the ratio Tm PAH /C In is correlated with time of exposure to ochratoxin A. The changes of renal structure were characterized by degeneration of the proximal tubules, leading to tubular atrophy accompanied by interstitial fibrosis. At the end of the experiment the kidney, liver, adipose and muscular tissue of the slaughtered pigs contained sizable amounts of ochratoxin A residues. As the pigs would have passed the meat inspection this represents a possible health problem. The changes observed in this study are identical to those observed by feeding to pigs grains naturally contaminated with ochratoxin A.