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POLYVINYLPYRROLIDONE‐STORAGE DISEASE.
Author(s) -
ReskeNielsen Edith,
BojsenMøller Marie,
Vetner Max,
Hansen Jens Carl
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1976.tb00133.x
Subject(s) - polyvinylpyrrolidone , eosin , pathology , haematoxylin , staining , congo red , medicine , biopsy , chemistry , organic chemistry , adsorption
The light and electron microscopical findings in the polyvinylpyrrolidone‐storage disease are reported on the basis of biopsies of skin, striated muscle, bone marrow and liver from one patient and a subcutaneous nodule from another patient. Both patients suffer from diabetes insipidus and have been treated for several years with Insipidin retard®, which contains polyvinylpyrrolidone (PVP) as the retarding agent. Deposits of PVP have been demonstrated in all the tissues examined and can easily be recognized by certain staining qualities. The combination of haematoxylin‐eosin, elastin (Weigert), alkaline Congo red and Sirius red for amyloid and PTAH is specially to be recommended. The ultrastructural findings consist of intracellular vacuoles containing a granular material and probably representing lysosomes. The final identification of the nature of the deposits has been made by spectrophotometric analysis. The suspicion of a case of PVP‐storage disease should result in a skin biopsy which usually is sufficient for the diagnosis.