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UROTHELIAL CHANGES OF THE RENAL PAPILLAE IN SPRAGUE‐DAWLEY RATS INDUCED BY LONG TERM FEEDING OF PHENACETIN
Author(s) -
Johansson Sonny,
Angervall Lennart
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1976.tb00130.x
Subject(s) - phenacetin , term (time) , kidney , medicine , endocrinology , pharmacology , physics , quantum mechanics
Thirty female Sprague‐Dawley rats were fed 0.535 per cent phenacetin in the diet for up to 110 weeks. Twenty‐six of these rats developed urothelial hyperplasia, partly papillary, of the renal papillae. Twenty‐eight rats showed dilatation of the vasa recta frequently associated with thrombus formation and calcification. One phenacetin fed rat had epithelial hyperplasia associated with chronic pyelitis. In 2 of the 30 control rats urothelial hyperplasia was found to be associated with chronic pyelitis. The hyperplastic urothelial changes and vascular changes were often, but not always, present simultaneously. One control rat developed a mammary carcinoma, as compared with 5 rats in the phenacetin group. Four phenacetin fed rats developed carcinoma of the ear duct. The results of the present investigation provide evidence that phenacetin can induce proliferative lesions of the urothelium of the rat renal pelvis with weak carcinogenic activity in the ear duct and mammary glands.