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HETEROGENEITY IN IN VITRO RESPONSE TO PROGESTERONE AND MELPHALAN OF MAMMARY TUMOURS INDUCED IN THE RAT BY 7,12‐DMBA
Author(s) -
Aspegren Knut,
Biörklund Anders,
Tropé Claes
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1976.tb00117.x
Subject(s) - dmba , melphalan , in vitro , endocrinology , medicine , chemistry , biology , cancer research , cancer , chemotherapy , biochemistry , carcinogenesis
Five mammary tumours induced in rats by 7, 12‐DMBA were each divided into four sections, and studied as cell suspensions in vitro for response to melphalan or progesterone measured as H 3 ‐thymidine incorporation. Heterogeneity towards melphalan and progesterone was found within all five tumours, but the mode of reaction of the two drugs differed. The biological relevance of these findings is discussed.