Premium
THE ALVEOLAR LINING LAYER IN EXPERIMENTAL PARAQUAT POISONING
Author(s) -
Robertson Bengt,
Grossmann Gertie,
Ivemark Biörn
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1976.tb00108.x
Subject(s) - alveolar epithelium , paraquat , pulmonary surfactant , lung , alveolar wall , pathology , epithelium , chemistry , alveolar macrophage , medicine , macrophage , biochemistry , in vitro
Rats were injected with paraquat, 35 mg/kg, and killed 8 or 12 hours later. Electron microscopic studies of the lungs revealed degenerative changes in alveolar epithelium and alveolar capillary endothelium after 8 hours. After 12 hours, the alveolar lining layer was contaminated with cellular debris from disintegrating alveolar epithelium. This contamination is probably responsible for the inactivation of lung surfactant that can be demonstrated in early stages of experimental paraquat poisoning.