Premium
BILE CANALICULAR ALKALINE PHOSPHATASE IN NECROPSY SPECIMENS OF THE LIVER AND ITS RELATION TO DISEASE
Author(s) -
Hägerstrand Inga
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1976.tb00100.x
Subject(s) - bone canaliculus , alkaline phosphatase , pathology , phosphatase , chemistry , medicine , biology , enzyme , biochemistry
The histochemical patterns of the alkaline phosphatase reaction in liver specimens obtained at 185 consecutive autopsies were studied for any correlation with clinical data and post mortem findings. Alkaline phosphatase activity of bile canaliculi was found in 71 per cent of the subjects with malignant tumours not involving the liver, and in 77 per cent of the subjects with malignant tumours involving the liver. The histochemical pattern did not differ with the type of tumour. Most subjects with rheumatoid arthritis as well as most of those with centro‐lobular hepatic necrosis due to heart incompensation also showed alkaline phosphatase activity in the bile canaliculi.