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BILE CANALICULAR ALKALINE PHOSPHATASE AND DISEASE
Author(s) -
Hägerstrand Inga
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1976.tb00099.x
Subject(s) - bone canaliculus , alkaline phosphatase , bile duct , pathology , disease , gastroenterology , medicine , biology , biochemistry , enzyme
The alkaline phosphatase reaction is normally absent in human bile canaliculi, but was found in 79 patients. In search for a common causal factor, these patients were further examined. Thirty‐seven were autopsied. The conditions most commonly associated with the phenomenon were malignant tumours with or without involvement of the liver, collagen diseases, longstanding partial obstruction of the common bile duct, and genetic variants of alpha‐1‐antitrypsin. No clinical or laboratory facts were common to all the patients.