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NUCLEAR SIZE CLASSES IN THE FOLLICULAR EPITHELIUM OF LYMPHOID THYROIDITIS
Author(s) -
Nilsson Göran
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1976.tb00086.x
Subject(s) - feulgen stain , thyroiditis , pathology , follicular phase , nuclear dna , biopsy , cell nucleus , epithelium , biology , chemistry , medicine , thyroid , endocrinology , nucleus , microbiology and biotechnology , staining , genetics , gene , mitochondrial dna
Nuclear size classes of the type originally described by Jacobj were studied in the follicular epithelium of biopsy smears from lymphoid thyroiditis. Thus, a great number of large nuclei in size classes distinct from the bulk of fairly identically sized nuclei could be clearly distinguished. By cytophotometric measurement of Feulgen‐DNA, these large nuclei were found to correspond closely to nuclei in separate DNA‐content‐classes and they were therefore called HDC‐nuclei ( H igh D NA‐quantity C lass nuclei). Such nuclei proved to be more common in lymphoid thyroiditis than in normal thyroids and non‐toxic goitres without lymphoid thyroiditis. Among lymphoid goitres, the percentage of HDC‐nuclei was positively correlated with the age of the patients. In the present paper, the relationship between Askanazy cells and HDC‐nuclei is also discussed.