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LYMPHOCYTE TRANSFORMATION IN VITRO IN DERMATOPHYTOSIS
Author(s) -
SVEJGAARD E.,
THOMSEN M.,
MORLING N.,
CHRISTIANSEN AA. HEIN
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1976.tb00063.x
Subject(s) - trichophyton rubrum , dermatophyte , antigen , epidermophyton floccosum , microsporum canis , trichophyton , immunology , candida albicans , microbiology and biotechnology , medicine , biology , antifungal
Peripheral blood lymphocytes from 59 patients with dermatophytosis and from nine young healthy women were studied by the lymphocyte transformation test (LT) using mitogens and bacterial as well as fungal antigens. The latter included Candida albicans (CA) and four dermatophyte species, viz. Trichophyton rubrum (TR), Trichophyton mentagrophytes (TM), Epidermophyton floccosum (EF) and Microsporum canis (MF). Most of the patients showed normal transformation in response to mitogens and non‐dermatophyte antigens, indicating that they have no functional T‐cell deficiency. Dermatophyte antigens act as stimulators in LT. In general, patient lymphocytes responded more strongly to these antigens than lymphocytes from controls. In most patients suffering from TM infections, response to the TM antigen was significantly stronger (p<0.05) than that in the other patients, indicating that this antigen preparation shows species specificity. In patients with Trichophyton (TR + TM) infections, response to the corresponding antigens was significantly stronger than that in the other patients, which suggests the existence of genus specificity. Any differences beween patients suffering from chronic TR infections and those with acute TR infections were not observed, a finding which is in contrast to those obtained in other studies. However, a few patients with chronic TM infections responded weakly to mitogens and non‐dermatophyte antigens. LT in four patients with id‐reaction to TM infection was not found to differ from that in the remaining TM patients.