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THE EFFECT OF NITROGEN MUSTARD ON HUMAN MONONUCLEAR BLOOD CELLS
Author(s) -
ØDEGAARD ARNE,
LAMVIK JON
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1976.tb00049.x
Subject(s) - nitrogen mustard , peripheral blood mononuclear cell , in vitro , human blood , cytotoxic t cell , pharmacology , drug , immunology , chemistry , biology , medicine , chemotherapy , biochemistry , physiology , cyclophosphamide
The effect of nitrogen mustard on the function of human blood monocytes and lymphocytes cultured in vitro , was studied. After a single in vitro exposure to the drug at culture start, an inhibition of the survival of non‐proliferating mononuclear phagocytes was observed. No immediate cytotoxic effect was registered. Nitrogen mustard given in therapeutic doses to patients with malignant lymphogranulomatosis did not reduce the survival of mononuclear phagocytes cultured at different times after the administration of the drug. Key words: Mononuclear blood cells; nitrogen mustard.