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EFFECT OF 2‐MERCAPTOETHANOL ON THE MIXED LEUKOCYTE REACTION IN MAN
Author(s) -
AXELSSON JANAXEL,
KÄLLÉN BENGT,
NILSSON OLLE,
TROPÉ GLAES
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1976.tb00046.x
Subject(s) - 2 mercaptoethanol , chemistry , transformation (genetics) , immunology , biophysics , biology , biochemistry , gene
When 2‐mercaptoethanol (2‐ME) is added to human mixed leukocyte cultures at the beginning of the culture period, only a very weak effect is seen. When 2‐ME is added after a few days' culture, a marked enhancement of cellular transformation occurs. 2‐ME can also enhance the effect of blastogenic factor (BF) containing media and it is possible that this effect depends on a stabilization or protection of BF preventing the break‐down of BF in cellular systems.