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ANTIBODIES TO SYNTHETIC ACTH IN ASTHMATIC AND RHEUMATIC PATIENTS
Author(s) -
JONSSON JONAS,
PEGELOW KJELLORVAR
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1976.tb00042.x
Subject(s) - medicine , antibody , incidence (geometry) , immunoglobulin e , gamma globulin , immunology , rheumatic fever , asthma , hemagglutination , gastroenterology , physics , optics
The prevalence of antibodies against synthetic ACTH preparations and porcine gamma globulin was investigated in 29 asthmatic patients, in 28 rheumatic patients, and in 63 normal subjects of both sexes. Agglutinating antibodies were examined by a passive haemagglutination test and IgE antibodies by a radio‐immuno assay. The incidence of agglutinating reactions against Synacthén® and porcine gamma globulin was significantly higher in the asthmatic and rheumatic groups than in the group of normal subjects. Titres were generally low, attaining supposedly pathological levels (≥ 1/200) in about 10 per cent of the asthmatic patients and in 20‐40 per cent of the rheumatic patients. In asthmatic patients, the incidence of ACTH specific IgE was higher than that in the normal group. This difference was not statistically significant in patients on routine treatment but it became satistically significant after ACTH booster treatment. In rheumatic patients the incidence of IgE antibodies against ACTH was significantly lower than that in the normal group. The incidence of agglutinating antibodies against vaso‐pressin in asthmatic and rheumatic patients was also increased as compared with that in normal subjects and the titres were positively correlated to those against ACTH.