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SYNERGISTIC EFFECT OF ALLOANTIBODIES OR F(ab') 2 AND PREDNISONE ON MURINE SPLIT HEART ALLOGRAFT SURVIVAL
Author(s) -
SCHILLING W.,
SVEHAG S.E.
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1976.tb00037.x
Subject(s) - prednisone , in vitro , incubation , heart transplantation , in vivo , transplantation , chemistry , medicine , andrology , immunology , pharmacology , biology , biochemistry , microbiology and biotechnology
Heterotopic grafting of split allogeneic mouse hearts across a strong H‐2 barrier (A/Sn → A.CA) was used in a study of alloantibody or F(ab') 2 induced enhancement. Strong specific binding of alloantibodies occurred in the graft. A marked synergistic effect on graft survival was observed after combined treatment of recipients with enhancing serum and prednisone. The highly dose‐dependent enhancing effect of F(ab') 2 was also strongly potentiated by supporting prednisone treatment. In vitro pre‐incubation of the heart tissue with alloantiserum or F(ab') 2 did not prolong graft survival; in contrast, C‐mediated damage of the graft was suggested when serum was used.