Premium
ALLO‐AGGRESSION IN CHICKENS
Author(s) -
CRONE MONNA,
SIMONSEN MORTEN
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1976.tb00036.x
Subject(s) - antibody , antiserum , antigen , immunization , microbiology and biotechnology , immunology , biology , peripheral blood
B1 ‐anti‐ B2 and B2 ‐anti‐ B1 allo‐antisera were raised by i.v. immunization of homozygous B 1/1 and B 2/2 chickens, respectively, with B 1/2 cells of the following sources: peripheral blood leucocytes (PBL), erythrocytes, thymus cells and bursa cells. Purified suspensions of these all produced anti‐B allo‐antibodies which could both haemagglutinate red blood cells and strongly inhibit the GVH reactivity of blood lymphocytes of the original donor type. Absorption studies of the sera using cells of the same four sources showed that they could all completely remove the GVH inhibitory antibodies. A fact of particular importance is that B‐haplotype determined antigens which are common to erythrocytes and lymphocytes seem to include the gene products of the allo‐aggression locus, as earlier defined (Simonsen 1975).