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STUDY OF SUBSTANCES RELATED TO CARCINOEMBRYONIC ANTIGENS, CEA‐NCA AND ASSOCIATION WITH α 1 ‐ANTICHYMOTRYPSIN
Author(s) -
ØRJASæTER HARALD
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1976.tb00025.x
Subject(s) - carcinoembryonic antigen , glycoprotein , immunoelectrophoresis , antigen , chemistry , microbiology and biotechnology , biochemistry , biology , immunology , medicine , cancer
The α‐protein which we previously detected in PCA extracts of malignant tumours, normal tissues, sera and other body fluids has been further tested. The α‐protein was identified by immunological methods as α 1 ‐antichymotrypsin. Experiments by crossed Immunoelectrophoresis showed that this protein cross‐reacts with the β E ‐protein found in the PCA extracts. The β E ‐protein shows heterogeneity in molecular size, electrophoretic mobility and it has been demonstrated that it shares antigenic determinants with the CEA or β 1 ‐molecule. Cross‐reaction between β E and other glycoproteins found in the PCA extract of normal or malignant tissue or serum was not detected.