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A LEUCOCYTE MIGRATION STUDY ON THE CELL‐MEDIATED IMMUNITY AGAINST ADULT HUMAN ORAL MUCOSA AND STREPTOCOCCAL ANTIGENS IN PATIENTS WITH RECURRENT APHTHOUS STOMATITIS
Author(s) -
Donatsky O.
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1976.tb00024.x
Subject(s) - antigen , microbiology and biotechnology , streptococcus , stomatitis , immunology , biology , oral mucosa , immunity , in vitro , streptococcus pyogenes , immune system , medicine , bacteria , staphylococcus aureus , anatomy , biochemistry , genetics
In vitro demonstration of cell‐mediated immunity (CMI) against adult human oral mucosa antigen (AHOM) and streptococcal antigens was accomplished by means of the leucocyte migration test (LMT) in patients with recurrent aphthous stomatitis (RAS). If antigenic extracts of AHOM, Streptococcus sanguis strain 2A or Streptococcus pyogenes strain M5 were used in the LMT experiments, the distribution of migration indices (MI) over patients with RAS differed significantly from the distribution over the controls. In patients with other oral lesions, these MI‐distributions did not differ significantly from those among the controls. Extracts of other tissues such as kidney and uterus tissues or of other bacterial antigens such as Brucella abortus and Escherichia coli did not reveal any significant differences between the LMT responses in RAS and controls. The present findings show that CMI against AHOM antigen and streptococcal antigens are features characteristic of RAS. Furthermore, the results indicate that common antigenic determinants might be shared by AHOM and streptococci.