Premium
RESTITUTION OF STREPTOZOTOCIN INDUCED DIABETES MELLITUS IN NUDE MICE WITH PANCREATIC GRAFTS FROM THE RAT
Author(s) -
BUSCHARD KARSTEN,
RYGAARD JORGEN
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1976.tb00023.x
Subject(s) - streptozotocin , diabetes mellitus , pancreas , transplantation , restitution , nude mouse , medicine , endocrinology , cancer , political science , law
Transplants of 1‐3 rat pancreases have proven to restitute streptozotocin induced diabetes in athymic nude mice. One out of 9 diabetic nude mice showed restitution following subcutaneous implantation of 1 rat pancreas. Three out of 6 nude mice were restituted by 2‐3 grafts. Implants of rat submandibular gland did not restitute nude mice similarly treated with streptozotocin. The model seems of interest in studies of inter‐species transplantation of pancreas.