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THE IMPACT OF HLA‐A, B OR HLA‐D IDENTITY ON THE MIF PRODUCTION IN MLC
Author(s) -
STENBJERG STENER,
MYGIND KIRSTEN,
JØRGENSEN FRITZ
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1976.tb00021.x
Subject(s) - linkage disequilibrium , human leukocyte antigen , allele , immunology , biology , hla a , genetics , antigen , gene , haplotype
The relative influence on MIF release in MLC of different parts of the HLA region was studied in 1) MLCs between cells from HLA‐A and B identical (probably HLA‐D unidentical) unrelated persons and 2) MLCs between cells from HLA‐D identical, HLA‐A and B unidentical unrelated persons. It was found that the HLA‐D part of the region has the major effect on the MIF production. Studies of MIF activity in supernatants from mitomycin treated cultures lent some evidence to the hypothesis that there is an extreme linkage disequilibrium between the HLA‐D alleles and hypothetical separate MIF alleles. Examination of families with crossover between the HLA‐A, B and HLA‐D part of the region is required for confirmation of these findings.