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INFLUENCE OF HYDROCORTISONE ON UPTAKE AND ELIMINATION OF 32 P‐LABELLED E. COLI BY RAT POLYMORPHONUCLEAR NEUTROPHILS (PMN) IN VITRO
Author(s) -
BAARDSEN A.
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1976.tb00010.x
Subject(s) - hydrocortisone , in vitro , chemistry , escherichia coli , bacteria , pharmacology , microbiology and biotechnology , biochemistry , biology , genetics , gene
Hydrocortisone was tested for inhibition of uptake and of elimination of E. coli by monolayers of rat peritoneal PMN. 32 P was used as label of the bacteria and their degradation products eliminated from the phagocytes. The cellular uptake was reduced by hydrocortisone (1‐2 mg per ml) both in the presence and absence of serum, while the elimination of bacterial label was reduced by 0.5 mg per ml and higher concentrations of the drug.