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INFLUENCE OF IgG, F(ab') 2 AND IgM ON THE PHAGOCYTIC AND BACTERICIDAL ACTIVITIES OF HUMAN NEUTROPHIL GRANULOCYTES
Author(s) -
CHRISTIE KAREN ELINA,
SOLBERG CLAUS O.,
LARSEN BODIL,
GROV ARNE,
TÖNDER OLAV
Publication year - 1976
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1976.tb00008.x
Subject(s) - phagocytosis , intracellular , microbiology and biotechnology , staphylococcus aureus , intracellular parasite , granulocyte , antibody , bacteria , immunoglobulin g , biology , opsonin , chemistry , immunology , biochemistry , genetics
The phagocytosis and intracellular killing of Staphylococcus aureus by human granulocytes in the presence of immunoglobulin preparations have been examined. Isolated IgG from pooled human serum induced phagocytosis and intracellular killing of bacteria. F(ab') 2 fragments had no significant effect, indicating that the Fc piece of the IgG molecule is of importance not only for the phagocytosis but also for the intracellular killing of bacteria. Isolated IgM stimulated the phagocytosis to a minor extent, with no enhancement of the bactericidal activity.