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EXPERIMENTAL RENAL CANDIDIASIS IN MICE AND GUINEA PIGS
Author(s) -
Winblad Bengt
Publication year - 1975
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1975.tb01890.x
Subject(s) - lumen (anatomy) , kidney , candida albicans , pathogenesis , genitourinary system , pathology , biology , medicine , anatomy , microbiology and biotechnology
As a part of an experimental study of the spread of urogenital infections, male guinea pigs and mice were intravenously injected with a sublethal dose of Candida albicans in a long‐time experiment. The kidney was the organ of maximum infection. Spread in the kidney was observed from the cortical and glomerular capillaries, where the injected yeast cells first lodged, but after pseudomycelial transformation penetrated into the Bowman's space and into the lumen of the tubuli. Guinea pigs recovered from the infection. In mice the renal candidiasis progressed and two types of the disease could be distinguished: an acute type with cortical abscesses and a chronic type with partly necrotic tips of the pyramids and adhering fungal masses in the pelves. A similar picture has been observed in man. The pathogenesis of renal candidiasis seems to resemble that of renal tuberculosis.