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MCG101‐AA, A NEW ASCITES TUMOUR IN C 57 MICE
Author(s) -
Hagmar Björn,
Ryd Walter
Publication year - 1975
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1975.tb01880.x
Subject(s) - neuraminidase , trypsinization , sialic acid , trypsin , cell , ascites , enzyme , neuraminic acid , microbiology and biotechnology , metastasis , chemistry , cancer research , biochemistry , pathology , biology , immunology , medicine , cancer
The transplantabilities of trypsin and neuraminidase‐treated 101‐AA cells were compared with untreated cells. The cell doses required for growth were similar for enzyme‐treated and control cells. Yet, trypsinized cells injected i.v. gave rise to less lung tumours and, in one experiment, they produced more extrapulmonary tumours than control cells or neuraminidase‐treated cells. These findings were collated with some data on the effect of enzyme treatment on the tumour cell membranes, obtained by particle size analysis, cell electrophoresis, lectin agglutinability and sialic acid determinations. The importance of cell surface characteristics for specific metastasis patterns, in this case a peculiar “myotrophism”, is discussed.