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PULMONARY VASCULAR LESIONS IN CHICKENS FOLLOWING INTRAVENOUS INJECTIONS OF DISINTEGRATED CELLS OF ESCHERICHIA COLI
Author(s) -
Nordstoga Knut,
Fjølstad Morten
Publication year - 1975
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1975.tb01875.x
Subject(s) - fibrinoid necrosis , pathology , escherichia coli , necrosis , medicine , peripheral blood mononuclear cell , giant cell , lung , mural cell , biology , vasculitis , smooth muscle , vascular smooth muscle , in vitro , disease , biochemistry , gene
Intravenous injections of disintegrated cells of Escherichia coli in chickens were almost constantly followed by extensive lesions in pulmonary arteries; the alterations consisted of mural fibrinoid necrosis, sometimes with slight intramural occurrence of mononuclear inflammatory cells and eosinophils. Massive perivascular accumulations of the same cell types were also very common findings. Affected arteries were frequently occluded by precipitates, predominantly consisting of the injected material, which were rapidly replaced by proliferating endothelial cells, resulting in obliterative lesions, where giant cells sometimes occurred. The conclusion was drawn that the arterial lesions could most adequately be categorized as hypersensitivity angiitis.