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THE CELLULAR RESPONSE IN REGIONAL LYMPH NODES AND THYMUS TO REPEATED APPLICATION OF OXAZOLONE TO THE SKIN
Author(s) -
Myking Andreas O.
Publication year - 1975
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1975.tb01656.x
Subject(s) - oxazolone , hyperplasia , lymph , germinal center , lymphatic system , pathology , lymph node , histology , repopulation , medullary cavity , chemistry , biology , medicine , immunology , antibody , microbiology and biotechnology , b cell , stem cell , haematopoiesis
The response of draining lymph nodes, thymus and skin to the repeated application of oxazolone was studied in mice by autoradiography, histology and the recording of organ weights. Transient paracortical hyperplasia was seen in the lymph nodes accompanied by rapid weight loss and depletion of cortical cells in the thymus. With regression of the paracortical hyperplasia, long‐lasting hyperplasia of germinal centres and medullary cords developed, while the thymus increased in weight with repopulation of the cortex. The findings suggest some kind of active control or inhibition of the paracortical reaction as the decline was observed during continuous oxazolone application.