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HETEROGENEITY OF PHAGOCYTIC MALFUNCTION IN MYELOID LEUKAEMIA
Author(s) -
Koch Christian
Publication year - 1975
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1975.tb01654.x
Subject(s) - myeloid , intracellular , myeloid leukaemia , myeloid cells , immunology , population , in vitro , medicine , biology , microbiology and biotechnology , genetics , environmental health
The capabilities of circulating leucocytes from 7 patients with chronic myeloid leukaemia (CML) and 3 patients with acute myeloblastic leukaemia (AML) to ingest and to kill Staphylococcus aureus in vitro were investigated. Defects in both of these two functions could be detected isolated or in combination. If these functional alterations were correlated with the morphology of the myeloid cell population, the most prominent finding was a highly significant correlation between decreased intracellular killing and degree of admixture of myelocytes and metamyelocytes to the mature cells. The data suggest that the main qualitative functional defect in CML as well as in AML is the inefficient intracellular killing capacity displayed by myelocytes and metamyelocytes. All, but one patient, were without signs of bacterial infection at the time of testing. The data thus add to the phenomena, previously observed in this laboratory concerning the killing defect, in severely infected patients, a defect which was found to be correlated in part with the degree of “shift to the left” of the myeloid cell population.