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THE BCG‐INDUCED RESISTANCE TO LISTERIOSIS
Author(s) -
Bennedsen J.,
Larsen S. Olesen
Publication year - 1975
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1975.tb01653.x
Subject(s) - vaccination , listeria monocytogenes , immunization , spleen , medicine , listeria , bcg vaccine , immunology , virology , vaccination schedule , bacilli , microbiology and biotechnology , biology , immune system , bacteria , genetics
BCG immunization schedules for the demonstration of resistance to listeriosis in C3H mice were re‐evaluated in a series of experiments. A two‐step procedure was found to be superior to a one‐step vaccination schedule. Reactivation with BCG five days before challenge caused a significant depression of the multiplication of Listeria monocytogenes in the spleen. A saline extract of tubercle bacilli was able to reactivate the BCG immunization in the “same way, even though a transient non‐immunogenic effect of the same extract was also demonstrated. In the two‐step procedure the vaccination dose was found to play a minor role, whereas the reactivation was dose‐dependent.