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FURTHER STUDIES OF THE CROSS‐REACTION BETWEEN KLEBSIELLA TYPE 12 AND TYPE 13 CAPSULAR POLYSACCHARIDES IN SERA FROM HYPERIMMUNIZED RABBITS
Author(s) -
Eriksen Jorunn
Publication year - 1975
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1975.tb01647.x
Subject(s) - klebsiella , antibody , klebsiella pneumoniae , microbiology and biotechnology , immunization , hemagglutination , polysaccharide , chemistry , antigen , biology , immunology , escherichia coli , biochemistry , gene
A cross‐reaction between Klebsiella types 12 and 13 polysaccharides was demonstrated in hyperimmunized rabbit sera. In most of the sera, the cross‐reaction could only be demonstrated by passive haemagglutination and not by precipitation. Immunization with Klebsiella type 13 induced antibodies of both the IgM and IgG class, but the antibodies cross‐reacting with Klebsiella type 12 polysaccharide were only IgM antibodies. In Klebsiella type 12 sera, the antibody activity was mainly, or only, demonstrated in the IgM class, none or only traces being found in IgG. Klebsiella type 12 antigen seemed to inhibit or delay production of IgG antibodies.