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ANTIGENICITY OF HUMAN IgM IN RELATION TO INTERACTION WITH STAPHYLOCOCCAL PROTEIN A
Author(s) -
Grov A.
Publication year - 1975
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1975.tb01646.x
Subject(s) - antigenicity , subclass , isotype , antibody , serology , antigen , immunoglobulin m , c reactive protein , chemistry , immunoglobulin g , immunology , biology , microbiology and biotechnology , monoclonal antibody , inflammation
Antibodies to protein A reactive and non‐reactive human IgM proteins were produced in rabbits. Serological examinations revealed antigenic determinant(s) of the protein A reactive IgM not present on the non‐reactive IgM. Isolated antibodies to this determinant(s) were shown to be capable of inhibiting interaction with protein A. Three IgM preparations from different pools of normal human sera were all found to contain protein A reactive fractions. The observed difference in protein A reactivity points to an isotype or subclass deviation of human IgM.