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INFLUENCE OF METHYLPREDNISOLONE AND AZATHIOPRINE ON POLYMORPHONUCLEAR NEUTROPHILS (PMN) IN RAT PERITONEAL EXUDATES
Author(s) -
Baardsen A.
Publication year - 1975
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1975.tb01644.x
Subject(s) - azathioprine , methylprednisolone , drug , pharmacology , medicine , chemistry , endocrinology , disease
In rats treated parenterally with high doses of methylprednisolone or azathioprine, peritoneal exudates were obtained by i.p. injection of sodium caseinate. Treatment by either drug caused a 50 per cent reduction of the PMN influx as compared to control animals simultaneously studied. The drug action evidently depends upon different mechanisms. Methylprednisolone blocked the emigration of PMN, while the low influx in the azathioprine‐treated rats was related to a lowered count of PMN in blood. The volume of exudates was not affected by drug treatment. The phagocytic activity of peritoneal PMN as expressed by uptake of 32 P‐labelled E. coli , was found to be intact in either group of drug‐treated rats.