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COMPLEMENT ACTIVATION IN MENINGOCOCCAL SEPTICEMIA
Author(s) -
Johnson Ulf,
Laurell AnnaBrita
Publication year - 1975
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1975.tb01640.x
Subject(s) - properdin , complement system , complement (music) , alternative complement pathway , immunology , classical complement pathway , meningococcal infections , medicine , chemistry , microbiology and biotechnology , biology , meningococcal disease , neisseria meningitidis , antibody , bacteria , biochemistry , genetics , gene , phenotype , complementation
Analyses of complement components in plasma from a patient with meningococcal septicemia showed abnormally low levels of C3 and properdin. C4 remained within the normal level. Activation of C3 proactivator and conversion of C3 was shown. Except these findings, which are in agreement with activation of complement by endotoxin by the alternate pathway, a marked decrease in Clq was observed.