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PARTICIPATION OF GRANULOCYTE‐SPECIFIC ANTINUCLEAR FACTORS IN RHEUMATOID JOINT FLUID CRYOPRECIPITATES
Author(s) -
Wiik Allan,
Jensen Erik,
Friis Johannes,
BachAndersen Rasmus
Publication year - 1975
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1975.tb01637.x
Subject(s) - cryoglobulins , cryoglobulin , rheumatoid factor , anti nuclear antibody , rheumatoid arthritis , medicine , synovial fluid , immunology , fibrinogen , pathology , immunoglobulin d , chemistry , antibody , cryoglobulinemia , autoantibody , osteoarthritis , hepatitis c virus , virus , alternative medicine , b cell
Cryoglobulins, isolated from synovial fluids of 42 rheumatoid arthritis patients and 18 osteo‐arthrosis patients were studied immunochemically and serologically. The concentrations of total protein, IgG and IgA were significantly higher in the rheumatoid cryoglobulins, while complement components were rare in both types of cryoglobulins. Fibrinogen antigens were commonly demonstrated in both rheumatoid and osteo‐arthrosis cryoglobulins. Granulocyte‐specific antinuclear factors belonging to the IgG and/or IgM classes were found in 62 per cent of the rheumatoid but none of the osteo‐arthrosis cryoglobulins. Organ‐nonspecific antinuclear factors were detected in 30 per cent and antiglobulins in 24 per cent of the rheumatoid cryoglobulins, while osteo‐arthrosis cryoglobulins were devoid of such activity. In a few cases antinuclear factors and antiglobulins were solely detected in the cryoglobulin and not in the corresponding joint fluid. A comparison between cryoglobulin and joint fluid IgG as to the relative content of IgG antinuclear factors in paired positive specimens may indicate enrichment of the cryoglobulins with granulocyte‐specific and organ‐nonspecific antinuclear factors. Our data are compatible with the notion that rheumatoid joint fluid cryoglobulins, at least in part, represent cold‐insoluble immune complexes composed of antinuclear factors and antiglobulins as well as nuclear antigens as shown by others.