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IgG ANTIBODIES TO IgA IN TWO PATIENTS WITH HYPOGAMMAGLOBULINAEMIA TREATED WITH COMMERCIAL GAMMAGLOBULIN
Author(s) -
Kamme Carl,
Dahiquist Erik,
Jonsson Svante,
Lindstrom Folke
Publication year - 1975
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1975.tb01625.x
Subject(s) - gamma globulin , antibody , immunology , medicine
Antibodies to IgA were detected in two males with hypogammaglobulinaemia. The antibodies were demonstrated to belong to the IgG class. In both patients low serum levels of IgG and IgM but no IgA were found. On two occasions one of the patients reacted with severe side reactions within a few seconds after an intramuscularly given injection of gammaglobulin. The other patient had received monthly intramuscular injections of gammaglobulin over a period of 2 years when the anti‐IgA antibodies first appeared and has since then been regularly treated for 1 1/2 years without any signs of adverse reactions. In five additional patients with hypogammaglobulinaemia and side reactions after i.m. injections of gammaglobulin no antibodies to IgA, IgG or Gm‐determinants were detected.