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HUMAN IgM INTERACTING WITH STAPHYLOCOCCAL PROTEIN A
Author(s) -
Grov Arne
Publication year - 1975
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1975.tb01622.x
Subject(s) - chemistry , c reactive protein , protein a , macroglobulinemia , sepharose , precipitation , microbiology and biotechnology , immunology , biology , biochemistry , antibody , physics , meteorology , multiple myeloma , inflammation , enzyme
IgM from 7 sera of patients with macroglobulinemia has been examined for interaction with staphylococcal protein A. Three of the IgM proteins were fixed to a protein A‐Sepharose column. They gave a direct co‐precipitation and the “star‐phenomenon”, but no direct precipitation in agar. The primary protein A reactive sites were localized to the Fc‐region, but co‐precipitation and “star”‐formation were also dependent on other molecular configurations. Two of the sera examined contained both protein A reactive and protein A non‐reactive IgM in different ratio.