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OCCURRENCE OF HEPATITIS B SURFACE ANTIGEN (HB s Ag) IN BLOOD DONORS AND PATIENTS SUFFERING FROM TRANSFUSION HEPATITIS
Author(s) -
Hansson B. G.,
Sundstrom G.,
Johnsson T.
Publication year - 1975
Publication title -
acta pathologica microbiologica scandinavica section c immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-1328
DOI - 10.1111/j.1699-0463.1975.tb01615.x
Subject(s) - medicine , radioimmunoassay , incidence (geometry) , antibody , blood transfusion , hepatitis b , antigen , hepatitis , gastroenterology , immunology , virology , physics , optics
A survey of the stock of registered blood donors in Malmö revealed 0.07 per cent carriers of hepatitis B surface antigen (HB s Ag) if tested with immunoelectroosmophoresis (IEOP). In the group of prospective donors, the IEOP technique detected HB s Ag at a frequency of 0.5 per cent, while a more sensitive solid‐phase radioimmunoassay (RIA) detected a further 0.1 per cent. The RIA technique used in this investigation showed an incidence of false positives of 0.5 per cent. Most of the falsely positive sera probably contained antibodies against guinea pig globulin thus interfering with the test. The incidence of suspected transfusion hepatitis decreased after the screening for HB s Ag among the blood donors was introduced. The justification of using RIA as screening method for HB s Ag is discussed.