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DIFFERENT EFFECTS ON RENAL AND SUBMAXILLARY RENIN RELEASE AFTER BLOCKADE OF THE RENIN SYSTEM IN MICE
Author(s) -
Bing Jens,
Poulsen Knud
Publication year - 1975
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1975.tb01404.x
Subject(s) - renin–angiotensin system , endocrinology , medicine , submaxillary gland , plasma renin activity , chemistry , blockade , kidney , receptor , blood pressure
Inhibition of the angiotensin I converting enzyme with SQ 20,881 results in a rapid marked increase in plasma renin concentration in mice. The maximum effect is short‐lasting, but the values are still elevated 2 hours after the injection, the time course being similar to that previously found in rats. The relative increase is the same in normal and sialo‐adenectomized mice. The plasma renin concentration of nephrectomized mice with their submaxillary glands intact is, however, totally uninfluenced by injection of the blocker. This finding indicates that renin release from the submaxillary glands is not controlled by the plasma angiotensin II concentration as is that of the renin release from the kidneys.