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MALIGNANT HYPERTHERMIA IN A FAMILY
Author(s) -
ReskeNielsen Edith,
Haase Jens,
Kelstrup Jørgen
Publication year - 1975
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1975.tb01394.x
Subject(s) - malignant hyperthermia , electron microscope , pathology , skeletal muscle , degeneration (medical) , anatomy , striated muscles , medicine , biology , chemistry , physics , optics
Twelve healthy relatives of two children who died of malignant hyperthermia—volunteered to give biopsies of striated muscle. Electron microscopy of their muscles revealed nonspecific myofibrillary degeneration and profound alterations of parts of muscle fibres. Furthermore, constructional faults were found in the architecture of the muscle. Previous investigations correlated with these abnormalities support the assumption, that inborn errors of metabolism may involve membranes of other tissues as well as striated muscle.