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EFFECTS OF SUPPLY AND WITHDRAWAL OF FLUORIDE.
Author(s) -
Rosenquist Jan B.
Publication year - 1975
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1975.tb01390.x
Subject(s) - fluoride , alkaline phosphatase , chemistry , ingestion , acid phosphatase , phosphatase , femur , enzyme , bone remodeling , medicine , endocrinology , biochemistry , surgery , inorganic chemistry
Growing rabbits were given 200 ppm of fluoride in the drinking water during 14 weeks. During this period excessive fluorotic changes developed in the diaphyses of the femur and tibia. The alkaline phosphatase and pyrophosphatase activities increased simultaneously in the fluorotic bone whereas the ratio between the activities remained constant. Acid phosphatase activity also increased. The increase in enzyme activities was regarded as due to the increased bone turnover and not as a primary consequence of fluoride ingestion.