Premium
THE USE OF PROTEIN A‐CONTAINING STAPHYLOCOCCI SENSITIZED WITH ANTI‐MENINGOCOCCAL ANTIBODIES FOR GROUPING NEISSERIA MENINGITIDIS AND DEMONSTRATION OF MENINGOCOCCAL ANTIGEN IN CEREBROSPINAL FLUID
Author(s) -
OLCÉN PER,
DANIELSSON DAN,
KJELLANDER JAN
Publication year - 1975
Publication title -
acta pathologica microbiologica scandinavica section b microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-131X
DOI - 10.1111/j.1699-0463.1975.tb00117.x
Subject(s) - neisseria meningitidis , microbiology and biotechnology , latex fixation test , direct agglutination test , antigen , neisseria , agglutination (biology) , meningococcal vaccine , meningococcal infections , antibody , neisseriaceae , biology , meningococcal disease , bacteria , immunology , antibiotics , serology , genetics
The co‐agglutination technique, utilizing antibody coated protein A‐containing staphylococci, was successfully adapted to grouping N. meningitidis strains. It was found to give more clear‐cut results than the standard slide test, especially in the case of strains isolated from throat specimens. The co‐agglutination technique has also other advantages over the standard slide test in the grouping of meningococci: minor influence by auto‐agglutination, higher specificity, easy performance and low consumption of specific antisera. Preliminary results also showed that the co‐agglutination technique could be applied for the rapid detection of meningococcal antigen in cerebrospinal fluid.