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TRANSPLANTABLE HAMSTER TUMORS INDUCED WITH THE BK VIRUS
Author(s) -
NÄSE L. M.,
KÄRKKÄINEN M.,
MÄNTYJÄRVI R. A.
Publication year - 1975
Publication title -
acta pathologica microbiologica scandinavica section b microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0304-131X
DOI - 10.1111/j.1699-0463.1975.tb00112.x
Subject(s) - hamster , virology , bk virus , virus , biology , cancer research , microbiology and biotechnology , genetics , kidney , kidney transplantation
Two tumors induced by BK virus in hamsters of an inbred strain were serially transplanted by subcutaneous injection of tumor explants. Both the original tumors as well as the transplants grew as solid, localized, encapsulated tumors. Histologically tumors were classified as fusocellular fibrosarcomas. Polymorphic tumor tissue was characterized by an abundance of collagen fibers and multinucleated giant cells. Cell lines established from tumors contained nuclear T antigen which stained with sera from a number of tumor‐carrying hamsters, but also with SV40 T antiserum. Virion antigens were not detected in these cell lines, and no virus was isolated when tumor extracts were inoculated in Vero cells.