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INTRACRANIAL TUMOURS INDUCED IN GUINEA PIGS WITH ROUS SARCOMA VIRUS
Author(s) -
Ahlström Carl Gustaf,
Olin Tord,
Smitterberg Bror
Publication year - 1974
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1974.tb03858.x
Subject(s) - pathology , rous sarcoma virus , sarcoma , medicine , skull , meningioma , anatomy , biology , virus , virology
Fifty newborn guinea pigs were inoculated intracranially with Rous Sarcoma virus strain Schmidt‐Ruppin (SR‐RSV). Neurological symptoms appeared after 3–7 weeks. Forty‐eight intracranial tumours were found in 27 guinea pigs. Ten guinea pigs showed meningeal tumours, in 10 guinea pigs the tumours were located intracerebrally and 7 showed both meningeal and intracerebral tumours. The meningeal tumours were either highly differentiated fibroma‐like, often growing in whorl‐like formations and sometimes invading the overlying skull bone or sarcomatous. Similar sarcomas with both argentophilic and glial fibrils were seen among the intracerebral tumours. The “mixed” character may be due to an inherent capacity of the tumour cells to produce both argentophilic and glial fibrils. Nine of the intracerebral tumours had the appearance of gliomas resembling the fibrillary astrocytomas or oligodendrocytomas in man. Angiographically arteriovenous shunts were seen in the sarcomatous intracranial tumours whereas displacement of the vessels was nearly absent in the poorly vascularized gliomas. The mengiomas received their blood supply from the external carotid artery although it would be supplied from the internal carotid artery if they had an intracerebral component.