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FOCAL AVILLOUS LESIONS IN THE GUINEA‐PIG DUODENUM INDUCED BY FASTING
Author(s) -
Poulsen Steen Seier
Publication year - 1974
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1974.tb03851.x
Subject(s) - duodenum , jejunum , guinea pig , pathological , medicine , gastroenterology , stimulation , pathology , physiology
In adult male guinea‐pigs exposed to total fasting avillous areas arose in the duodenum, and sometimes in the proximal jejunum, in the course of 12–18 hours. The lesions increased in extent during the first 2–3 days, whereupon the condition was stationary until the animals had been fasted for 5–7 days. Then the villi started regenerating. After 9 days' fasting the small intestinal appearance might be completely normal. The pathological process by which the avillous surface formed is described after periodic‐Schiff (PAS) stained whole mounts had been studied in the stereomicroscope and by conventional histological methods. It is suggested that the reaction is elicited by the acid gastric juice which is being secreted in spite of lacking stimulation by food. The appearances are compared with those which may be found in patients with the Zollinger‐Ellison syndrome or with duodenal ulcer.