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SKIN GRAFTS IN NUDE MICE
Author(s) -
Rygaard Jørgen
Publication year - 1974
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1974.tb03831.x
Subject(s) - nude mouse , spleen , biology , lymph , pathology , immunology , medicine , genetics , cancer
Avian, reptilian and normal human skin grafts are well accepted by the nude mouse, as demonstrated by this and other studies. Histological studies show consistently good incorporation of grafts, and changes in spleen and lymph nodes similar to those observed after other transplants in the animal. The consensus of studies evidence that the nude mouse is the least resistant recipient of grafts of diverse origin among the experimental animals, prepared or otherwise, which are under study today. This is an expression of the extent of the immunological deficiency in the nude. An interesting question asked by Calne in 1970 can be answered. Though its ‘milieu interieur’ could be thought to be widely different from the avian and the reptilian, the nude mouse is an adequate host of avian and reptilian tissue.