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SKIN GRAFTS IN NUDE MICE
Author(s) -
Rygaard Jørgen
Publication year - 1974
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1974.tb03830.x
Subject(s) - cytotoxic t cell , skin grafting , transplantation , antibody , strain (injury) , skin transplantation , mouse strain , graft rejection , andrology , immunology , biology , medicine , surgery , anatomy , in vitro , genetics , gene
Nude mice of each of the three genetic backgrounds BALB/c, C3H, and C57/BL readily accept skin heterotransplants from inbred Fischer strain rats and other rat strains. Second set transplants from the same donors are also readily accepted. In all instances graft take was uneventful, and the final appearance of grafts was as in normal animals of the donor strain. This event contrasts strongly with that observed in similar nude mice receiving allotransplants. Allograft take was delayed, and although ultimate acceptance was virtually 100 per cent, many grafts evidenced endogenous damage occurring during the acceptance process. This damage was manifested by tufted irregular hair growth in many cases, and by bare atrophic, though vital, areas of graft skin. Also strikingly contrasting were the findings that allografting in nude mice excited no cytotoxic antibody response, while cytotoxic antibody titres in serum of nude mice receiving heterotransplants were moderate to high. Thymus grafting confers capacity for heterograft rejxsection.