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SKIN GRAFTS IN NUDE MICE
Author(s) -
Rygaard Jørgen
Publication year - 1974
Publication title -
acta pathologica microbiologica scandinavica section a pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0365-4184
DOI - 10.1111/j.1699-0463.1974.tb03829.x
Subject(s) - spleen , lymph , red pulp , white pulp , pathology , biology , transplantation , immunology , lymph node , lymphatic system , cytotoxic t cell , chimera (genetics) , gene , medicine , genetics , in vitro
Mice, homozygous for the nu gene ( nude mice), have no capacity for rejection of allografts as evidenced by this study of nine different graft‐host combinations. The mice concerned stem from an intermediate stage in a nu gene transfer to three inbred strains (BALB/c, C3H, C57/BL). Mice of each of the three genetic backgrounds accepted skin grafts from three inbred donor strains, differing at the H‐2 locus. A preliminary comparison with a concurrent study of heterografts (rat skin) indicates that allografts are not so readily incorporated, and are more prone to endogenous damage during the take process. This paradoxical observation is discussed at greater length in the subsequent article on heterotransplants in nude mice. After allografting, nude mice display lymphocytosis, and there is lymphoid cell proliferation in the primary follicles of lymph nodes, and increased numbers of mononuclear cells are seen in the paracortex of lymph nodes and in the red pulp of the spleen. No cytotoxic alloantibodies could be demonstrated in serum from the graft bearing nude mice. Thymus grafting confers capacity for allograft rejection.